Dynamics of changes in tumor-associated macrophages in patients with primary skin melanoma depending on the method of surgical treatment

Summary : Skin melanoma is one of the deadliest among human skin tumors, and surgery remains first main method in its combined treatment. Despite seemingly radical nature surgical interventions patients with primary melanoma, frequency locoregional recurrence metastasis high. The question impact treatment on evolution microenvironment unclear. Aim to investigate dynamics polarization tumor-associated macrophages stage 0-IIa subsequent metastatic lesions assess postoperative ischemia survival patients. Results it was found that plastic replacement a tissue defect, compared conventional suturing, can lead decrease density intrastromal distribution pro-inflammatory CD68 + focus, as well less frequent TAM cells M2 direction migration component tumor, their more mixed content, which, result, affects this category for better. Conclusions closing defect may affect duration cells. Plastic after tumor removal improves five-year rates (PFS by 22,6 % (p = 0.003) OS 13,1% 0.029).